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Santa Ana is a city with an area of 71.0 km² (27.4 mi²) and a population of 337,977 people Search and find <strong>companies</strong>, telephone numbers, addresses, email addresses in the <em>Business Directory Santa Ana</em> Santa Ana is the largest city and the county seat of Orange County, California. It lies approximately 10 miles inland from the Pacific Ocean, on the largely seasonal Santa Ana River. The Santa Ana Freeway runs through the city, and the Costa Mesa Freeway and Garden Grove Freeway travel along its edges. It is today best-known for its enormous Mexican-American population, now comprising over 75% of what was once a virtually all-white city. The Current OMB metropolitan designation for Santa Ana and the Orange County Area is “Santa Ana-Anaheim-Irvine, CA.”